Cell host & microbe | 2021
Brain development in premature infants: A bug in the programming system?
Abstract
In this issue of Cell Host & Microbe, Seki et\xa0al. (2021) demonstrate an overgrowth of Klebsiella in the gut microbiota of extremely premature infants that is predictive of brain damage. The Klebsiella-associated pro-inflammatory signature suggests that aberrant microbiome-gut-brain axis signaling provokes the disruption of neurodevelopmental trajectories to exacerbate brain injury.