Clinical Genitourinary Cancer | 2019
Solitary Mucinous Prostate Adenocarcinoma Lung Metastasis Detected by 68Ga‐PSMA‐11 PET/CT
Abstract
Mucinous adenocarcinoma of the prostate is a rare subtype of prostate cancer characterized by the presence of at least 25% of the tumor composed of glands with intracellular mucin. Lung is the second most common extranodal site of metastases after bone. However, solitary lung metastasis fromprostatecancer,withoutosseousor lymphatic involvement, is considered as a rare condition. Locating one single site of recurrence in the early phase of biochemical recurrence is important in order to select the most appropriate therapeutic approach with curative intent, such as metastasis-directed therapy. 68-Gallium prostate-specific membrane antigen (68GaPSMA-11) positron emission tomography/computed tomography (PET/CT) has a high sensitivity for detecting small site of recurrent prostate cancer at low prostatespecific antigen (PSA) levels. In this case report, 68-Ga-PSMA-11 PET/CT detected a solitary mucinous lung metastasis from prostate cancer (negative with 18F-fluorodeoxyglucose PET/ CT and 18F-fluciclovine PET/CT) in a patient with biochemical recurrence after prostatectomy at low PSA levels, leading to metastasis-directed therapy with curative intent.