Reference values for the phase angle of the electrical bioimpedance: Systematic review and meta-analysis involving more than 250,000 subjects.

Abstract

BACKGROUND & AIMS\nThe bioimpedence phase angle has been considered as a predictor for morbidity and mortality in different clinical situations, although reference values from a large healthy population are lacking. The aim of this meta-analysis is to estimate mean phase-angle values in healthy individuals.\n\n\nMETHODS\nThis meta-analysis systematically searched MEDLINE, EMBASE, The Cochrane Controlled Trials Register, SCIELO, LILACS, CINAHL, Web of Science and gray literature for studies estimating mean phase angles. Quality of evidence was assessed for all studies and subgroup (males and females) meta-analysis stratified by age group according to literature (up to 2; 3-5; 6-12; 13-15; 16-18; 19-28; 29-38; 39-48; 49-58; 59-69; 70-80 and\xa0>80 years of age) were conducted using random-effects models.\n\n\nRESULTS\nA total of 46 studies including 249,844 subjects were selected for the present analysis. Males show a pooled estimate of the mean phase angle of 3.6 (95% CI: 3.0-4.1) for infants (0-2\xa0y), increasing progressively to 7.3 (95% CI: 7.0-7.5) at the teenage phase (16-18\xa0y), stabilizing during adult ages (18-38) and decreasing progressively with ongoing years with an estimate of 5.3 (95% CI: 4.5-6.0) for elderly above 80 years old. Similarly, females start from 3.7 (95% CI: 3.2-4.3) for infants (0-2\xa0y), increasing progressively to 6.4 (95% CI: 6.1-6.8) at the teenage phase (16-18\xa0y), stabilizing during adult ages (18-48) and decreasing progressively with ongoing years with an estimate of 5.4 (95% CI: 5.3-5.6) for elderly above 80 years old. Also, males have higher estimates than females for all age groups except for infants (0-2) and subjects older than 80 years old. Heterogeneity was high for all age groups.\n\n\nCONCLUSIONS\nIn both sexes, phase-angle values have a similar pattern that start from infants, increase progressively up to the teenage phase, stabilize during adult ages, and then decrease progressively in older subjects and the elderly.