Deep attention branch networks for skin lesion classification.

Abstract

BACKGROUND AND OBJECTIVE\nThe skin lesion usually covers a small region of the dermoscopy image, and the lesions of different categories might own high similarities. Therefore, it is essential to design an elaborate network for accurate skin lesion classification, which can focus on semantically meaningful lesion parts. Although the Class Activation Mapping (CAM) shows good localization capability of highlighting the discriminative parts, it cannot be obtained in the forward propagation process.\n\n\nMETHODS\nWe propose a Deep Attention Branch Network (DABN) model, which introduces the attention branches to expand the conventional Deep Convolutional Neural Networks (DCNN). The attention branch is designed to obtain the CAM in the training stage, which is then utilized as an attention map to make the network focus on discriminative parts of skin lesions. DABN is applicable to multiple DCNN structures and can be trained in an end-to-end manner. Moreover, a novel Entropy-guided Loss Weighting (ELW) strategy is designed to counter class imbalance influence in the skin lesion datasets.\n\n\nRESULTS\nThe proposed method achieves an Average Precision (AP) of 0.719 on the ISIC-2016 dataset and an average area under the ROC curve (AUC) of 0.922 on the ISIC-2017 dataset. Compared with other state-of-the-art methods, our method obtains better performance without external data and ensemble learning. Moreover, extensive experiments demonstrate that it can be applied to multi-class classification tasks and improves mean sensitivity by more than 2.6% in different DCNN structures.\n\n\nCONCLUSIONS\nThe proposed method can adaptively focus on the discriminative regions of dermoscopy images and allows for effective training when facing class imbalance, leading to the performance improvement of skin lesion classification, which could also be applied to other clinical applications.