Current Biology | 2019
Cell Death: N-degrons Fine-Tune Pyroptotic Cell Demise
Abstract
The N-end rule pathway mediates the degradation of proteins through their destabilizing amino-terminal residues. While previously implicated in apoptosis regulation, N-end rule degradation has now recently been shown to fine-tune pyroptotic cellular demise through the amino-terminal degradation of the inflammasome component NLRP1B.