Frequency of insulin resistance in nondiabetic adult Bangladeshi individuals of different obesity phenotypes.

Abstract

Insulin resistance (IR) is the corner stone of metabolic obesity. This cross-sectional analytical study was aimed to find out the frequency of IR in non-diabetic adult individuals of different obesity phenotypes that would help to implement preventive measures to avoid the cardiometabolic catastrophes.\n\n\nMETHODS\nTotal 955 nondiabetic adult individuals were selected and categorized into six metabolic phenotypes by metabolic syndrome criteria in each BMI group (18.5-24.9-normal weight, 25-29.9-overweight, ≥30-obese). From them, metabolically obese normal weight, metabolically obese overweight, metabolically healthy obese and metabolically unhealthy obese were selected as Obesity phenotypes (N\u202f=\u202f616).\n\n\nRESULTS\nThe frequency of IR was found to be very high (60.2%) in total nondiabetic adult obese individuals (N\u202f=\u202f616). Highest frequency of IR was found in MUO phenotype (76.3%), lowest frequency of IR was found in MONW phenotype (37.1%) and frequency of IR in MOOW and MHO phenotypes found to be identical but significantly (p\u202f<\u202f0.0001) less than MUO and significantly (p\u202f<\u202f0.0001) more than MONW phenotype. Among the obesity phenotypes, females were more insulin resistant than males (67.5% vs 48.1% respectively, p\u202f<\u202f0.05). Frequency of IR found significantly (p\u202f<\u202f0.05) more in female than male in all obesity phenotypes except in MUO phenotype where males found to show significantly (p\u202f<\u202f0.05) higher frequency than females. Frequency of IR was significantly higher in younger (20-39\u202fyrs) age group than 40-60\u202fyrs age group (63.2% vs 53.5% respectively, p\u202f<\u202f0.05).\n\n\nCONCLUSION\nIR is alarmingly high (60.2%) in nondiabetic adult obese individuals. Among different obesity phenotypes, it is highest (76.3%) in MUO and lowest (37.1%) in MONW.