European journal of obstetrics, gynecology, and reproductive biology | 2019
Adjuvant chemoradiotherapy versus radiotherapy in cervical cancer patients with intermediate-risk factors: A systematic review and meta-analysis.
Abstract
BACKGROUND\nAt present, extensive hysterectomy and pelvic lymph node dissection are preferred for early-stage cervical cancer. However, additional adjuvant therapy could be considered if there is a risk for recurrence. Postoperative pelvic radiotherapy plus concurrent platinum-based chemotherapy are recommended for patients with high risk factors. The treatment regimen for patients with intermediate-risk factors, however, remains unclear. We, thus, performed a systematic review and meta-analysis to assess the recurrence-free survival (RFS), overall survival (OS), grade III/IV hematologic toxicity and grade III/IV non-hematologic toxicity in chemoradiotherapy (CRT) versus radiotherapy (RT) groups.\n\n\nMETHODS\nWe systematically searched PubMed, Cochrane, and Embase to identify relevant studies published before November 30, 2018 to compare CRT with RT as a postoperative adjuvant therapy in early-stage cervical cancer patients with intermediate-risk factors. We used Stata (version 14.0) to calculate odds risks (ORs) and 95% confidence intervals (CIs) and pooled data was assessed by the fixed-effects model.\n\n\nRESULTS\nOf the 428 identified studies, only 9 were eligible and included in our analysis (CRT: n\u2009=\u2009870; RT: n\u2009=\u2009932). CRT significantly prolonged RFS (OR\u2009=\u20093.43, 95% CI 2.08-5.67, P\u2009=\u20090.000) and OS (OR\u2009=\u20091.80, 95% CI 1.30-2.50, P\u2009=\u20090.000). The occurrence rate of grade III/IV hematologic toxicity (OR\u2009=\u200916.07, 95% CI 6.47-39.93, P\u2009=\u20090.000) was significantly higher in CRT, while grade III/IV non-hematologic toxicity was ambiguous for CRT and RT with an OR of 1.91 (95% CI 0.95-3.83, P\u2009=\u20090.069).\n\n\nCONCLUSIONS\nFor early-stage cervical cancer patients with intermediate-risk factors, CRT can dramatically improve RFS and OS compared with RT. Apart from the increase in grade III/IV hematologic toxicity, CRT was well tolerated and accepted treatment for early-stage cervical cancer.