Probiotics for the treatment of women with bacterial vaginosis: A systematic review and meta-analysis of randomized clinical trials.

Abstract

This systematic review and meta-analysis systematically evaluated the efficacy of probiotic monotherapy and combination therapy for bacterial vaginosis (BV). Published randomized controlled trials were searched in the Cochrane Library, PubMed, EMBASE, OVID Database and ClinicalTrials.gov from the inception dates to 12 July 2019. The literature was screened and evaluated according to the inclusion criteria, and the data were analysed by a random effect model. A chi-square test was used to test heterogeneity between trials. This study included 14 randomized controlled trials (RCTs), which included 1372 patients, and the cure rate of BV was analysed. Three RCTs compared probiotics with a placebo (control) [risk ratios (RR)\u202f=\u202f4.39, 95% CI (2.05, 9.41), P\u202f=\u202f0.0001]. Two RCTs compared probiotics with antibiotics (control) [RR\u202f=\u202f1.03, 95% CI (0.38, 2.81), P\u202f=\u202f0.95]. The remaining 9 RCTs compared the combination of probiotics and antibiotics with antibiotics alone [RR\u202f=\u202f1.28, 95% CI (1.05, 1.56), P\u202f=\u202f0.02]. Despite the high heterogeneity of the pooled analysis, neither the subgroup analysis results nor the sensitivity analysis results were statistically significant. Probiotics may have a positive effect on the treatment of BV, but there is a lack of strong evidence.