Cine MRI characterizes HFpEF and HFrEF in post-capillary pulmonary hypertension.

Abstract

PURPOSE\nTo test the hypothesis that cine MRI can be used to characterize features of left and right ventricles in post-capillary pulmonary hypertension (PH) caused by heart failure (HF) with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF).\n\n\nMETHODS\nWith the approval of institution review board (IRB), 28 consecutive post-capillary PH patients (11 males, 62.1\u2009±\u200913.4 years old, range 39-89 years old) underwent cine MRI scans. Cine MRI-derived left ventricular (LV) ejection fraction (LVEF) and other function, motion, and deformation indices (acquired with heart deformation analysis [HDA]) were compared between PH-HFpEF (defined as LVEF\u2009≥\u200950 %]) and PH-HFrEF (LVEF\u2009<\u200950 %) patients and were related with right ventricular (RV) indices and right heart catheterization (RHC)-derived pulmonary artery measurements.\n\n\nRESULTS\nTotally 19 patients (68 %, 95 % confident interval [CI] 49 %-86 %) were assigned to PH-HFpEF group while 9 (32 %) was assigned to the PH-HFrEF group. There were differences of LV and right ventricular (RV) global functional indices, LV mass, LV displacement, velocity, strain and strain rate between the two patient groups. Cine MRI-derived LV indices had broad associations with RV indices and RHC measurements. LVEF was negatively correlated with pulmonary capillary wedge pressure (PCWP) (r = -0.5, p\u2009=\u20090.007). LV cardiac index (LVCI) was associated with systolic pulmonary artery pressure (sPAP) (r\u2009=\u20090.443, p\u2009=\u20090.018).\n\n\nCONCLUSIONS\nPH-HFpEF and PH-HFrEF patients present dissimilar function, motion and deformation features in LV and RV. Cine MRI-derived LV measures are correlated with hemodynamic abnormalities of PH.