Building resource constraints and feasibility considerations in mathematical models for infectious disease: A systematic literature review

Abstract

Highlights • Mathematical model capabilities to explore complex systems now enable priority-setting to consider local resource constraints.• Common objectives of model-based analyses incorporating constraints are to assess real-world feasibility or allocate resources efficiently.• Constraints may be incorporated via (i) model-based estimation; (ii) linkage of mathematical and health system models; or (iii) optimisation.• Models can then project constrained intervention effects and costs and resource requirement s for delivering interventions at full scale.• Health system constraints should be systematically defined for routine operationalisation in model-based priority-setting.