Comparative evaluation of inflammatory parameters and substitute insulin resistance indices in elderly women with and without type 2 diabetes mellitus

Abstract

PURPOSE\nTo analyze the influence of inflammatory parameters and substitute insulin resistance indices on the risk of type 2 diabetes mellitus (DM) development in elderly women, as well as to compare anthropometric measures and metabolic parameters according to the presence of type 2 DM and HbA1c levels.\n\n\nPATIENTS AND METHODS\nOne hundred and twenty elderly women (67.9\u202f±\u202f6.0\u202fyears) were submitted to anthropometric analysis, determination of inflammatory and metabolic parameters. They also underwent indices of lipid accumulation product (LAP), high density triglyceride/lipoprotein ratio (TG/HDL), triglyceride glucose index (TyG), as well as TyG by body mass index (BMI) ratio (TyG-BMI) assessment.\n\n\nRESULTS\nBody mass index, tumor necrosis factor alpha, interleukin-2, blood glucose, TG, LAP, TG/HDL, TyG and TyG-BMI were significantly higher in elderly women with DM compared to non-diabetic women. LAP ≥ 55.4 (OR\u202f=\u202f2.29; P\u202f=\u202f.027); TyG\u202f≥\u202f8.8 (OR\u202f=\u202f3.52; P\u202f<\u202f.001) and TyG-BMI\u202f≥\u202f264.8 (OR\u202f=\u202f3.54; P\u202f=\u202f.001) were identified as risk factors for DM.\n\n\nCONCLUSION\nHigh pro-inflammatory parameters, low levels of anti-inflammatory markers and higher levels of substitute insulin resistance indices are risk predictors for DM development in elderly women in primary health care.