Left lateral segment liver volume is not correlated with anthropometric measures.

Abstract

BACKGROUND\nLiver transplantation is definitive therapy for end stage liver disease in pediatric patients. Living donor liver transplantation (LDLT) with the left lateral segment (LLS) is often a feasible option. However, the size of LLS is an important factor in donor suitability - particularly when the recipient weighs less than 10\xa0kg. In the present study, we sought to define a formula for estimating left lateral segment volume (LLSV) in potential LLS donors.\n\n\nMETHODS\nWe obtained demographic and anthropometric measurements on 50 patients with Computed Tomography (CT) scans to determine whole liver volume (WLV), right liver volume (RLV), and LLSV. We performed univariable and multivariable linear regression with backwards stepwise variable selection (p\xa0<\xa00.10) to determine final models.\n\n\nRESULTS\nOur study found that previously reported anthropometric and demographics variables correlated with volume were significantly associated with WLV and RLV. On univariable analysis, no demographic or anthropometric measures were correlated with LLSV. On multivariable analysis, LLSV was poorly predicted by the final model (R2\xa0=\xa00.10, Coefficient of Variation [CV]\xa0=\xa042.2) relative to WLV (R2\xa0=\xa00.33, CV\xa0=\xa018.8) and RLV (R2\xa0=\xa00.41, CV\xa0=\xa015.8).\n\n\nCONCLUSION\nPotential LLS living donors should not be excluded based on anthropometric data: all potential donors should be evaluated regardless of their size.