Transcatheter ablation of the Atrio-ventricular junction in refractory atrial fibrillation: A clinic-pathological study.

Abstract

BACKGROUND\nCatheter ablation of the specialized atrioventricular junction (AVJ) with a right-side approach is an effective therapy for refractory atrial fibrillation with fast ventricular rate. Our aim is to assess the efficacy of the procedure in a single center experience and investigate the histologic findings of AVJ after catheter ablation.\n\n\nMETHODS\nA) Analysis of AVJ ablation efficacy in a consecutive series of patients with refractory atrial fibrillation; B) Histo-pathologic study of the conduction system by serial section technique and clinical-electrophysiologic correlation in four patients who underwent AVJ ablation.\n\n\nRESULTS\nA) Right sided AVJ ablation was successful in all 87 consecutive patients (mean procedural time 19.2±17.9\u202fmin). Energy applications ranged from 1 to 27 (mean 5.8±5.1) with eight patients (9%) requiring > 15 applications. B) Fibrotic disruption of AV node and/or His bundle interruption was found in three cases with previous AVJ ablation. In the case requiring a left side approach, the compact AV node and common His bundle appeared undamaged whereas extensive fibrosis of the summit of the ventricular septum, branching His bundle and proximal bundle branches was found.\n\n\nCONCLUSION\nOur data confirm that the ideal site for ablation of the specialized AVJ is the AV node. In selected cases with unsuccessful AV node ablation, a shift towards the His bundle is needed. A continuity between the septal and anterior leaflets of the tricuspid valve may protect the His bundle as to require multiple shocks and prolong the procedure.