Proteinuria in Hantavirus Cardiopulmonary Syndrome: a frequent finding linked to mortality.

Abstract

OBJECTIVES\nTo determine the relative frequency and prognosis value of proteinuria in hantavirus cardiopulmonary syndrome (HCPS) due to Andes virus.\n\n\nMETHODS\nThis is an observational analytical study with prospectively obtained data from patients admitted to 12 health centers in 9 Chilean cities between 2001 and 2018. Only patients with confirmed Andes virus HCPS and laboratory characterization that included qualitative proteinuria determination at admission were considered.\n\n\nRESULTS\nOur database involved 175 patients, 95 of them had measurement of urine protein at the time of hospital admission. They were mainly male (71%) and the median age in years was 35[22-47].Their median duration of the febrile prodromal time was 5[4-7] days. Hospital length of stay and hospital mortality rate were 10[7-14] days and 21.1%, respectively. We identified 73 patients (77%) with proteinuria at admission, which was associated with increased mortality rate (26% versus 5%, p=0.036) and the relative risk was 1.3 [1.1-1.6], p=0.002.\n\n\nCONCLUSIONS\nIn patients with HCPS, proteinuria is a frequent finding which is associated with a higher mortality rate.