Assessment of event-related evoked potentials and China-Wechsler intelligence scale for cognitive dysfunction in children with obstructive sleep apnea.

Abstract

OBJECTIVE\nTo explore the relationship between obstructive sleep apnea (OSA) and cognitive impairment by combining event-related evoked potentials (ERPs) and China-Wechsler Younger Children Scale (C-WISC) in children with sleep-disordered breathing (SDB) with vs. without OSA.\n\n\nMETHODS\nThis was a retrospective case-control study of all consecutive children (n\xa0=\xa0148) with adenoid tonsil hypertrophy between July 2017 and March 2019\xa0at the Hospital.\n\n\nRESULTS\nThe children were divided into the OSA (n\xa0=\xa0102) and non-OSA (n\xa0=\xa046) groups. The apnea-hypopnea index (AHI), obstructive\u2002apnea\u2002index (OAI), and obstructive apnea-hypopnea index (OAHI) in the OSA group were elevated compared with those of the non-OSA group (all P\xa0<\xa00.001). The mean oxygen saturation (SaO2) and SaO2 nadir were lower in the OSA group compared with the non-OSA group (both P\xa0<\xa00.001). The respiratory arousal index (RAI) values in the OSA group were larger than those of the non-OSA group (P\xa0<\xa00.001). The P300 and N100 latencies in the OSA group were longer than those of the non-OSA group (both P\xa0<\xa00.001). Pearson s correlation analysis revealed correlations of the P300 peak latency with full-scale intelligence quotient (FIQ) (P\xa0<\xa00.001 and r\xa0=\xa0-0.527), verbal intelligence quotient (VIQ) (P\xa0<\xa00.001 and r\xa0=\xa0-0.448), and performance intelligence quotient (PIQ) (P\xa0<\xa00.001 and r\xa0=\xa0-0.515). There was a correlation between the N100 peak latency and PIQ (P\xa0=\xa00.026 and r\xa0=\xa0-0.183).\n\n\nCONCLUSION\nERPs, as an objective measurement, might help assess cognitive impairment in children with OSA.