Associations of CD14 variants with the triglyceride levels and risk of myocardial infarction in an Eastern Chinese Han population.

Abstract

BACKGROUND\nCD14 is crucial in the progression of myocardial infarction (MI). Several studies have explored the association between the risk of MI and the CD14 C-260\xa0T polymorphism, but have reported inconsistent results.\n\n\nMETHODS\nThis study analyzed the association of the CD14 C-260\xa0T polymorphism with susceptibility to MI. Totally, 240 MI patients and 298 normal subjects were included. The association between MI risk and the target polymorphism was assessed using 95% confidence intervals and odds ratios obtained through logistic regression.\n\n\nRESULTS\nThe T allele of the CD14 C-260\xa0T polymorphism was linked with an elevated risk of MI in Chinese Han people; subgroup analysis indicated that this effect was associated with smoking, male gender, and hypertension. In addition, the data revealed that different genotype carriers of the CD14 C-260\xa0T polymorphism showed significantly distinct TG levels in MI patients.\n\n\nCONCLUSION\nTotally, the T allele of the CD14 C-260\xa0T polymorphism is associated with an elevated risk of MI.