Inflammatory dietary pattern and incident psoriasis, psoriatic arthritis, and atopic dermatitis in women: A cohort study.

Abstract

BACKGROUND\nDiet is a modulator of inflammation that might impact inflammatory skin diseases.\n\n\nOBJECTIVE\nTo assess the relationship between pro-inflammatory dietary patterns and incident psoriasis, psoriatic arthritis (PsA), and atopic dermatitis (AD).\n\n\nMETHODS\nWe conducted cohort studies among women in the Nurses Health Study II. The Empirical Dietary Inflammatory Pattern (EDIP) score was calculated at baseline and every 4\xa0years. Incident psoriasis, PsA, and AD were assessed by validated self-report. We used multivariable-adjusted Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between EDIP quintiles and risk for psoriasis, PsA, and AD.\n\n\nRESULTS\nWe had 85,185 participants in the psoriasis analysis and 63,443 in the AD analysis. There were 1432 cases of psoriasis, 262 cases of PsA, and 403 cases of AD. Pro-inflammatory dietary patterns were not associated with the risk for outcomes in multivariable models (all P values for trend >.05). HRs comparing the highest to the lowest EDIP quintile were 0.99 (95% CI 0.83-1.18) for psoriasis, 1.22 (95% CI 0.81-1.83) for PsA, and 0.96 (95% CI 0.69-1.34) for AD.\n\n\nLIMITATIONS\nRecall and self-report.\n\n\nCONCLUSION\nOur findings do not support dietary inflammatory potential as a risk factor for psoriasis, PsA, or AD.