Genetic ancestry differences in pediatric asthma readmission mediated by socio-environmental factors.

Abstract

BACKGROUND\nSocial and financial hardships explain approximately 50% of the observed disparity in asthma-related readmissions between Black and White children.\n\n\nOBJECTIVES\nTo determine whether asthma-related readmissions differed by degree of African ancestry and the extent to which such an association would also be explained by socio-environmental risk factors.\n\n\nMETHODS\nThis study used data from a prospective cohort study of 695 Black and White children aged 1-16 years with an asthma-related admission. The primary outcome was a similar readmission within 12 months. Each subject s African ancestry was determined by single nucleotide polymorphisms, on a continuous scale ranging from 0-1 (0=no African ancestry; 1=100% African ancestry). We also assessed 37 social, environmental, and clinical variables that we clustered into six domains (e.g., hardship, disease management). Survival and mediation analyses were conducted.\n\n\nRESULTS\nA total of 134 (19.3%) children were readmitted within 12 months. Higher African ancestry was associated with asthma readmission (OR 1.11, 95% CI: 1.05-1.18 for every 10% increase in African ancestry) with adjustment for age and sex. The association between African ancestry and readmission was mediated by hardship (sβ=3.42, p<0.001) and disease management (sβ=0.046, p=0.001), accounting for >50% of African ancestry s effect on readmission. African ancestry was no longer significantly associated with readmission (sβ=0.035, p=0.388) after accounting for these mediators.\n\n\nCONCLUSIONS\nAfrican ancestry was strongly associated with readmission and the association was mediated by family hardships and disease management. These results are consistent with the notion that asthma-related racial disparities are driven by factors like structural racism and social adversity.