PREDICTION OF BRAIN AGE USING RESTING-STATE FUNCTIONAL CONNECTIVITY REVEALS ACCELERATED AGING IN THE PRECLINICAL PHASE OF AUTOSOMAL DOMINANT ALZHEIMER’S DISEASE, IRRESPECTIVE OF AMYLOID PATHOLOGY

Abstract

P1-024 PREDICTION OF BRAIN AGE USING RESTING-STATE FUNCTIONAL CONNECTIVITY REVEALS ACCELERATED AGING IN THE PRECLINICAL PHASE OFAUTOSOMAL DOMINANTALZHEIMER’S DISEASE, IRRESPECTIVE OFAMYLOID PATHOLOGY Julie Gonneaud, Alexis Baria, Alexa Pichet Binette, Tammie L. S. Benzinger, John C. Morris, Randall Bateman, John C. S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, the DIAN Study Group, and the PREVENT-AD Research Group, McGill University, Montreal, QC, Canada; Douglas Mental Health Research Institute, Montreal, QC, Canada; Centre for Studies on Prevention of Alzheimer’s disease, Douglas Mental Health Institute, Montreal, QC, Canada; Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Knight Alzheimer’s Disease Research Center, St. Louis, MO, USA; Knight Alzheimer Disease Research Center, St. Louis, MO, USA; Northwestern University, Chicago, IL, USA. Contact e-mail: [email protected]