Alzheimer s & Dementia | 2019
Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies
Abstract
Understanding the heterogeneous pathology in Alzheimer s disease and related tauopathies is one of the most urgent and fundamental challenges facing the discovery of novel diseaseâmodifying therapies. Through monitoring ensembles of toxic and nontoxic tau oligomers spontaneously formed in cells, our biosensor technology can identify tool compounds that modulate tau oligomer structure and toxicity, providing much needed insight into the nature and properties of toxic tau oligomers.