Alzheimer s & Dementia | 2019
AN EHR-BASED COHORT DISCOVERY TOOL FOR IDENTIFYING PROBABLE AD
Abstract
neuropsychological test scores in older surgical patients presenting for elective spine operations. Methods: This was a prospective cohort study of 52 patients aged 65-89 years, having elective, inpatient spine surgery under general anesthesia. To determine the validity of cognitive screening using the Mini-Cog, we compared Mini-Cog scores with neuropsychological test scores. Neuropsychological tests included Digit Symbol Substitution to test attention and concentration, Animal Category Fluency and Trail Making Tests A & B to test executive function, and CERADWord List Delayed Recall, Logical Memory Immediate & Delayed Recall to test Memory. Clinical Dementia Rating (CDR) and Instrumental Activities of Daily Living (IADL) were also assessed. Results: Of 52 patients enrolled, 9 patients scored between 0-2 (compatible with cognitive impairment) on the Mini-Cog, while 43 scored between 3-5. There were significant differences between the two groups in Digit Symbol Substitution Test scores (p1⁄40.02), CERAD Word List Delayed Recall (p1⁄40.05), Trail Making Test A (p<0.001), and Trail Making Test B (p<0.01). (See table) Of note, there was no difference between the two groups Mini-Mental State Examination scores. The two groups also had significantly different Clinical Dementia Ratings (p1⁄40.02) and Instrumental Activities of Daily Living scores (p<0.01). Conclusions: These data support the validity of administering the Mini-Cog as a brief screening tool for cognitive impairment in older patients presenting for elective spine surgery. P4-554 AN EHR-BASED COHORT DISCOVERY TOOL FOR IDENTIFYING PROBABLE AD Donna Tjandra, Raymond Migrino, Bruno Giordani, Jenna Wiens, University of Michigan, Ann Arbor, MI, USA; Phoenix Veterans Affairs Health Care System, Phoenix, AZ, USA. Contact e-mail: [email protected]