Association of Hospital Procedural Volume With Outcomes of Percutaneous Left Atrial Appendage Occlusion.

Abstract

OBJECTIVES\nThe aim of this study was to examine the association between percutaneous left atrial appendage occlusion (LAAO) procedural volume and in-hospital outcomes.\n\n\nBACKGROUND\nSeveral studies have demonstrated an inverse volume-outcome relationship for patients undergoing invasive cardiac procedures. Whether a similar association exists for percutaneous LAAO remains unknown.\n\n\nMETHODS\nPatients undergoing LAAO in 2017 were identified in the Nationwide Readmissions Database. Hospitals were categorized into 3 groups on the basis of tertiles of annual procedural volume: low (5 to 15 cases/year), medium (17 to 31 cases/year), and high (32 to 211 cases/year). Multivariate hierarchical logistic regression and restricted cubic spline analyses were performed to examine the association of hospital LAAO volume and outcomes. The primary outcome was in-hospital major adverse events (MAE), defined as a composite of mortality, stroke or transient ischemic attack, bleeding or transfusion, vascular complications, myocardial infarction, systemic embolization, and pericardial effusion or tamponade requiring pericardiocentesis or surgery.\n\n\nRESULTS\nThis study included 5,949 LAAO procedures performed across 196 hospitals with a median annual procedural volume of 41 (interquartile range: 25 to 67). Low-volume hospitals had higher rates of in-hospital MAE (9.5% vs. 5.6%; p\xa0<\xa00.001), stroke or transient ischemic attack (2.1% vs. 1.3%; p\xa0=\xa00.049), and bleeding or transfusion (6.1% vs. 3.5%; p\xa0=\xa00.002) compared with high-volume hospitals. No differences were noted for other components of MAE and index length of stay. On multivariate analysis, higher procedural volume was associated with lower rates of in-hospital MAE, with an adjusted odds ratio for medium versus low volume of 0.69 (95% confidence interval: 0.46 to 1.04; p\xa0=\xa00.08) and for high versus low volume of 0.55 (95% confidence interval: 0.37 to 0.82; p\xa0=\xa00.003).\n\n\nCONCLUSIONS\nHigher hospital procedural volume is associated with better outcomes for LAAO procedures. Further\xa0studies are needed to determine if this relationship persists for long-term outcomes.