Amnion membrane allografts in a critically ill infant with Netherton syndrome–like phenotype

Abstract

INTRODUCTION Netherton syndrome (NS) is a triad of nonbullous congenital ichthyosiform erythroderma, typical hair dysplasia, and severe atopic features. The incidence is 1 in 50,000 births, with 18% of all congenital erythrodermas attributed to NS. The skin is noted to be abnormal at birth or within the first month of life. Complications include thermoregulatory problems, electrolyte imbalances, hypernatremic dehydration, recurrent or severe infections, and failure to thrive. Skin hygiene represents a challenge in critically ill and unstable patients. This report describes a novel approach to skin management in NS.