The use of dupilumab for the treatment of recalcitrant brachioradial pruritus

Abstract

BRP: brachioradial pruritus INTRODUCTION Acquired cutaneous brachioradial pruritus (BRP) is a neuropathic condition that presents with intense itching and burning along the dorsolateral forearm and significantly impacts patients’ quality of life. Although there are treatment options that may prove effective, there is limited literature regarding guidelines for BRP patients who are resistant to first-line therapies. Here, we describe a case of BRP that was refractory to numerous topical and systemic treatments and eventually showed remarkable improvement with dupilumab, a biologic agent that modulates cytokines involved in the type 2 helper T-cell response. We also examine the pathophysiology of this condition and provide commentary on the use of dupilumab for the treatment of BRP.