The Journal of investigative dermatology | 2021
Capturing New Disease Genes in Psoriasis and Other Skin Diseases.
Abstract
Regulatory regions of the genome harbor most genetic variance associated with skin diseases. Because gene-regulatory networks are cell-type and cell-state specific and are subject to variation from the genetic background, current cell models that link genetic variation to gene expression are imperfect. Emerging single-cell genomics approaches may provide a new approach to understand the genetics of common skin diseases.