A convolutional-recurrent neural network approach to resting-state EEG classification in Parkinson’s disease

Abstract

BACKGROUND\nParkinson s disease (PD) is expected to become more common, particularly with an aging population. Diagnosis and monitoring of the disease typically rely on the laborious examination of physical symptoms by medical experts, which is necessarily limited and may not detect the prodromal stages of the disease.\n\n\nNEW METHOD\nWe propose a lightweight (∼20K parameters) deep learning model to classify resting-state EEG recorded from people with PD and healthy controls (HC). The proposed CRNN model consists of convolutional neural networks (CNN) and a recurrent neural network (RNN) with gated recurrent units (GRUs). The 1D CNN layers are designed to extract spatiotemporal features across EEG channels, which are subsequently supplied to the GRUs to discover temporal features pertinent to the classification.\n\n\nRESULTS\nThe CRNN model achieved 99.2% accuracy, 98.9% precision, and 99.4% recall in classifying PD from HC. Interrogating the model, we further demonstrate that the model is sensitive to dopaminergic medication effects and predominantly uses phase information in the EEG signals.\n\n\nCOMPARISON WITH EXISTING METHODS\nThe CRNN model achieves superior performance compared to baseline machine learning methods and other recently proposed deep learning models.\n\n\nCONCLUSION\nThe approach proposed in this study adequately extracts spatial and temporal features in multi-channel EEG signals that enable accurate differentiation between PD and HC. The CRNN model has excellent potential for use as an oscillatory biomarker for assisting in the diagnosis and monitoring of people with PD. Future studies to further improve and validate the model s performance in clinical practice are warranted.