MRI findings at neurological onset predict neurological prognosis in hemorrhagic shock and encephalopathy syndrome

Abstract

BACKGROUND\nHemorrhagic shock and encephalopathy syndrome (HSES) is a devastating disease and has an uncertain pathogenesis. The aim of this study was to predict neurological outcomes for HSES using magnetic resonance imaging (MRI) findings at neurological onset and elucidate the pathophysiology of HSES in the acute phase from serial MRI changes.\n\n\nMATERIALS AND METHODS\nWe analyzed the MRI findings of 13 patients who underwent an initial MRI within 24\xa0h of neurological onset. According to neurological prognosis, seven patients were included in the severe group and six in the non-severe group. All patients in the non-severe group had a follow-up MRI. We divided the whole brain into 14 regions and each region was scored according to diffusion-weighted imaging findings. We compared the total scores of each region between the two groups and between onset and follow-up MRI.\n\n\nRESULTS\nAt neurological onset, symmetrical lesions were found predominantly in the frontal, parietal, and occipital lobes in 12 of 13 patients (92%). In the severe group, the total score for onset MRI was significantly higher than those in the non-severe group (p\xa0=\xa00.003). The total score was significantly higher for follow-up than those of onset MRI (p\xa0=\xa00.036). White matter lesions that showed a bright tree appearance were observed in the follow-up MRIs of all patients.\n\n\nCONCLUSION\nTotal scores for onset MRIs are useful for predicting neurological prognosis in patients with HSES. In addition to widespread cortical involvement of predominantly watershed areas, white matter lesions may play a role in the progression of brain edema.