An Open Fetal Myelomeningocele Repair With Incorporation of a Skin Allograft.

Abstract

BACKGROUND\nMyelomeningocele (MMC) is the most frequent congenital abnormality of the central nervous system that leads to significant physical disabilities. Historically, treatment involved postnatal repair with management of the hydrocephalus with ventricular shunting. Animal and early human studies demonstrated the feasibility of fetal closure. The benefit of in-utero closure was debated until the results of the prospective randomized multicenter Management of Myelomeningocele Study (MOMS trial) were published, demonstrating a decreased need for shunting, reversal of hindbrain herniation, and better neurologic function in the prenatal repair group compared to postnatal repair. Fetal MMC closure has become a standard of care option for prenatally diagnosed spina bifida. The size of the spinal defect may require modification of the classic surgical technique requiring patching.\n\n\nCASE\nThis report describes a case of open fetal myelomeningocele repair, which required incorporation of a skin allograft.\n\n\nCONCLUSION\nLarge myelomeningocele defects may be successfully repaired with utilization of a skin allograft.