Multidisciplinary Clinical Considerations in the Treatment of Pediatric Epithelial Ovarian Cancer.

Abstract

BACKGROUND\nEpithelial ovarian cancers are a rare subset of the <1% of ovarian cancers diagnosed in children. This case highlights considerations when caring for these patients.\n\n\nCASE\nEvaluation of a 12-year-old post-menarchal girl presenting with suprapubic pain revealed a solid/cystic pelvic mass involving bilateral adnexa and elevated CA-125. Diagnostic laparoscopy pathology confirmed low-grade papillary serous ovarian carcinoma. Treatment involved surgical tumor debulking, hysterectomy, bilateral salpingo-oophorectomy, and omentectomy; adjuvant chemotherapy with no residual disease and normalization of CA-125; and an aromatase inhibitor for maintenance.\n\n\nSUMMARY AND CONCLUSION\nIn children with adult-type gynecologic cancers necessitating treatments including surgical sterilization and hormone-modulating therapy, psychological support and developmentally-informed collaboration between adult and pediatric services is essential. Clinical decisions for long-term bone and sexual health present opportunities for future research.