Ovarian tumors in children: how common are lesion recurrence and metachronous disease? A UK CCLG Surgeons Cancer Group nationwide study.

Abstract

BACKGROUND\nOvarian tumors in children are rare, mature teratoma being the most common histological entity. Robust guidelines to aid patient follow-up after resection are distinctly lacking. Although mature teratoma has a very good prognosis following complete resection, small studies have reported the occurrence of metachronous disease and recurrence to a variable degree (2.5-23% of patients). Nevertheless, there are surgeons who recommend no follow-up is required for these children after primary tumor resection. We investigated the incidence of (i) recurrence and (ii) metachronous disease in pediatric patients following ovarian tumor resection.\n\n\nMETHODS\nRetrospective multicenter study amongst UK pediatric surgical oncology centers. Females <16\u202fyears with diagnosis of ovarian tumor from 2006 to 2016 were included. Functional/neonatal ovarian cysts were excluded.\n\n\nRESULTS\nThree hundred ten patients with ovarian tumors treated at 12 surgical oncology centers were identified. Mean age at surgery was 11\u202fyears [IQR 8-14]. Most common diagnosis were mature teratoma (57%, 177 cases), immature teratoma (10.9%, 34 cases) and serous cystadenoma (7.7%, 24 cases). 8.1% (25 cases) of all females were identified with tumor recurrence/ metachronous disease. 5.1% (9 cases) of patients with mature teratoma had recurrent/ metachronous disease. Most of these patients were diagnosed at routine clinic follow-up.\n\n\nCONCLUSION\nOur study clearly shows that ovarian tumor recurrence(s) and metachronous disease occur, even in benign ovarian tumors. We recommend female pediatric patients should have robust follow-up care plans after primary diagnosis and resection of ovarian tumor(s).\n\n\nLEVEL OF EVIDENCE STATEMENT\nThis is a level II evidence study. It is a retrospective multicentre collaborative study which summarizes data from a national cohort of children.