Synthesis of cerium oxide nanoparticles loaded on chitosan for enhanced auto-catalytic regenerative ability and biocompatibility for the spinal cord injury repair.

Abstract

Biomedical applications like spinal cord injury repair; anticancer requires functional platforms and specific properties like antioxidant, autocatalytic and biocompatibility. This work demonstrated the synthesis of CeO2 nanoparticles which is shown to have promising applications in various fields exclusively biomedical field like scavenging of reactive oxygen species which is mainly responsible for carcinogenic effects. CeO2 nanoparticles were synthesized using the biocompatible ionic liquid followed by their loading with biopolymeric chitosan which was obtained by the deacetylation processing of chitin arrived from the shells of crab. The prepared CeO2 samples were characterized using FT-IR, XRD, SEM and TEM studies. FT-IR studies illustrated the formation of CeO2 nanoparticles and their loading with chitosan. A morphological study reveals the CeO2 nanoparticles are in the nano-size range of 15-20\u202fnm with the uniformly distributed spherical shaped structure. Exploited CeO2 nanoparticles with the biocompatible property may improve outcomes profound with the pharmaceutical applications. The results of UV-visible spectrum were established that addition of cerium oxide nanoparticles into the chitosan polymer has great ability of catalytic oxidative recovery from the spectrum shifting from lower to higher and higher to lower oxidation states. This specifies that cerium oxide nanoparticles loaded material has been provided enhanced auto-regenerative and neuroprotective activity in spinal card regeneration.