Viscus fat area contributes to the Framingham 10‐year general cardiovascular disease risk in patients with type 2 diabetes mellitus

Abstract

Objective: To explore the correlation of the viscus fat area (VFA) with the Framingham 10‐year general cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 202 patients with T2DM were divided into two groups based on VFA (a VFA ≥ 100 cm2 group and a VFA < 100 cm2 group), or four groups based on sex and age (a middle‐aged male group, an elderly male group, a middle‐aged female group, and an elderly female group). The correlation between the Framingham 10‐year general cardiovascular disease risk and body fat indexes was analyzed. Results: Patients in the VFA ≥ 100 cm2 group had higher body fat indexes and Framingham Risk Scores (FRSs) and lower levels of high density lipoprotein‐cholesterol (HDL‐C) when compared to the VFA < 100 cm2 group (P < 0.05). Female patients had higher body fat mass (BFM) and body fat percentage (BFP) levels and a lower VFA when compared to male patients. The VFA was significantly higher in the elderly than in the middle‐aged patients. The waist hip fat ratio (WHFR) was significantly higher in elderly females than in elderly males (P < 0.05). Elderly females had the highest FRS of all patients. Multiple stepwise regression analysis revealed the VFA as a contributor to the Framingham 10‐year general cardiovascular disease risk after statistical correction for other multiple factors affecting cardiovascular disease risk. Conclusion: The VFA is an independent factor that contributes to the Framingham 10‐year general cardiovascular disease risk in patients with T2DM.