Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults

Abstract

OBJECTIVE\nTo study the associations of dietary factors with S-Klotho plasma levels in young adults. We also aimed to study whether body composition and cardiometabolic risk factors affected the association between dietary factors and S-Klotho plasma levels.\n\n\nMETHODS\nA total of 139 young adults took part in this study. Dietary factors were measured using a food frequency questionnaire and three non-consecutive 24\u2009h recalls. S-Klotho plasma levels were measured by immunosorbent assay. Body composition was measured by DXA.\n\n\nRESULTS\nWe observed a direct association of ethanol intake and S-Klotho plasma levels in women. An inverse association was also observed between the dietary inflammatory index (DII) with S-Klotho plasma levels in all sample. No mediation effects of body composition or cardiometabolic risk factors were observed in the relationship between alcohol and S-Klotho plasma levels. Lean mass index (LMI) and uric acid levels mediated the relationship between DII and S-Klotho plasma levels.\n\n\nCONCLUSION\nA pro-inflammatory dietary pattern was inversely associated with S-Klotho plasma levels in young adults, which was partially mediated by LMI and uric acid levels.