Continuous Blood Glucose Monitoring to Determine Glycemic Variability in Patients Having COVID-19 Infection and Its Bearing on the Severity of the Disease

Abstract

Aimsa study to determine the effect of glycemic variability measured by continuous blood glucose monitoring as assessed by standard deviation of each SARS CoV -2 patient s mean glucose level. Study designcross-sectional observational study of 13 patients with SARS CoV2 infection with acute respiratory syndrome. Place and duration of study : Department of Medicine, Dhiraj Hospital, Smt. Bhikhiben Kanjibhai Shah Medical College and Research Institute; between June 2020 to July 2020. Result13 patients were enrolled in the study, the median age of the enrolled patients was 55±12 years. Out of the 13 patients 5 patients belonged to mild and severe category of ARDS and 3 patients belonged to moderate. There was a gradual rise in inflammatory markers such as serum LDH, Ferritin, CRP from mild to severe ARDS and D-dimer level was more than double in severe category as compared to mild ARDS. Normal glycemic variability in adults is 3±2 , we found that there was a significant corelation of glycemic variability with severity of the disease with mean standard deviation of severe ARDS patients was 27.44 as compared to 19.26 and 9.7 of moderate and mild ARDS patients respectively. Hypoglycemia was documented in 10 patients. The maximum stay in the hospital was that of the patients with high glycemic variability that is 22±2 days. Conclusionthe preliminary study confirms linear relation between glycemic variability, severity of the disease and the duration of the hospital stay in patients of severe SARS CoV-2 with ARDS.