Early neuroaxonal injury is seen in the acute phase of pediatric optic neuritis.

Abstract

BACKGROUND\nThinning of the retinal nerve fiber layer (RNFL) and ganglion cell/inner plexiform layer (GCIPL) occur in the chronic phase after optic neuritis (ON) in children and reflect neuroaxonal injury. The objective of this study was to describe changes in RNFL and GCIPL thickness in the acute phase following pediatric ON.\n\n\nMETHODS\nData were collected prospectively from consecutive children presenting with ON as part of an incident acquired demyelinating event. Children with a final diagnosis of multiple sclerosis (n\u202f=\u202f9, 10 ON-affected eyes) or monophasic demyelination (n\u202f=\u202f16, 25 ON-affected eyes) who underwent spectral-domain optical coherence tomography (OCT) testing within 30 days of symptom onset were included. Standardized visual assessment was performed at presentation and 6-18 months follow-up. OCT measures were compared to those of healthy controls (n\u202f=\u202f25, 50 eyes).\n\n\nRESULTS\nMedian (interquartile range [IQR]) global RNFL thickness was increased in ON-affected eyes (155\xa0μm [114-199\xa0μm]) compared to control eyes (104\xa0μm [98.5-107.5\xa0μm]; p\xa0<\xa00.0001). Compared to controls, fellow eyes demonstrated a reduced temporal quadrant RNFL thickness (59\xa0μm [53-72\xa0μm] versus 71.5\xa0μm [65-81\xa0μm]; p\u202f=\u202f0.013) and lower GCIPL thickness (80.5\xa0μm [74-88\xa0μm] versus 87\xa0μm [85-89\xa0μm]; p\u202f=\u202f0.003). The ON-affected eyes of children with monophasic demyelination demonstrated a greater global RNFL thickness (183.5\xa0μm [146.5-206\xa0μm]) compared to the ON-affected eyes of children with multiple sclerosis (108.5\xa0μm [95-124\xa0μm]; p\u202f=\u202f0.01). OCT measures at presentation did not predict low-contrast visual acuity nor color vision at 6-18 months follow-up.\n\n\nCONCLUSION\nChildren with multiple sclerosis show less RNFL swelling in their ON-affected eyes at onset compared to children with monophasic demyelination. Lower GCIPL and temporal RNFL thickness in the clinically unaffected eyes of those children with unilateral ON suggests the presence of pre-existing neuroaxonal injury in children presenting with a first episode of ON. This finding may be driven by the subset of children with multiple sclerosis.