Biocompatibility of strontium incorporated ceramic coated titanium oxide implant indented for orthopaedic applications

Abstract

Abstract Titanium and its alloys are the most commonly used materials for manufacturing orthopaedicimplants. Various surface modifications are done in titanium alloys to improve osseointegration as well as for long term success of endosseous implants. In the present study preclinical safety evaluation of two nanoporous mixed metal oxide bone implant materials, TiO2-Nb2O5 (TN) and Sr-HAP modified TN (TNS) were assessed by in vitro and in vivo methods. The surface morphological analysis of fabricated materials was done by XRD, IR and SEM. The biocompatibility evaluations performed were In vitro cytotoxicity tests using L929 cells, Assessment of hemolytic properties of materials and Test for local effects after implantation in bone as per international standards. The results of the study conclude that the materials, TN and TNS are non-cytotoxic, non-hemolytic and biocompatible and can be used safely for orthopaedic applications.