Negative affect amplifies the relation between appetitive-food-related neural responses and weight gain over three-year follow-up among adolescents

Abstract

Highlights • Interaction of negative affect and hippocampal food-image response predicts BMI gain.• Interaction of negative affect, vermis and precuneus food response predicts BMI gain.• Interaction of stress and middle occipital gyrus milkshake response predicts BMI gain.• Weight gain associated with restrained eating and eating-disorder related behavior.