NeuroImage : Clinical | 2021
Cumulative exposure to ADHD medication is inversely related to hippocampus subregional volume in children
Abstract
Highlights • Cumulative exposure to ADHD medication characterized as the product of lifetime duration and dose.• Medication effects investigated on 51 subregional volumes.• Smaller hippocampus CA1 volumes associated with higher medication exposure.• Effects remained when correcting for age and ADHD symptom severity.• No global effects of medication on cortical thickness or surface area detected.