Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial.

Abstract

OBJECTIVES\nThe aim of this study was to explore the effect of resveratrol supplementation on lipid profile in individuals with dyslipidemia.\n\n\nMETHODS\nApparently healthy men and non-pregnant women 20 to 65 y of age with new diagnosis of dyslipidemia were enrolled in a randomized double-blind, placebo-controlled trial and randomly allocated to receive either resveratrol 100 mg/d or placebo (sucrose 0.5 g/d) for 2 mo. Smoking, alcohol intake, diabetes, acute or chronic renal or hepatic diseases, malignancy, cardiovascular disease, serum triacylglycerol levels ≥400 mg/dL, low-density lipoprotein cholesterol levels ≥190 mg/dL, and consumption of lipid-lowering drugs or supplements containing resveratrol were exclusion criteria.\n\n\nRESULTS\nSeventy-one individuals with new diagnosis of dyslipidemia were enrolled and randomly allocated to the resveratrol (n\u202f=\u202f35) or placebo groups (n\u202f=\u202f36). At baseline, there were no significant differences between the study groups. After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4 ± 34.4 versus 220.6 ± 37.4, P\u202f=\u202f0.04) and triacylglycerol (133.4 ± 55.3 versus 166.7 ± 68.5, P\u202f=\u202f0.04) concentrations compared with the placebo group, without significant statistical differences for high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels.\n\n\nCONCLUSION\nThe results suggest that resveratrol supplementation significantly reduces total cholesterol and triacylglycerol concentrations in individuals with dyslipidemia.