Gender differences in the relationship between prescription opioid misuse and depressive symptoms and suicidality among US High School Students.

Abstract

BACKGROUND\nPrescription opioid misuse and suicide among adolescents are significant health challenges.\n\n\nPURPOSE\nThis study investigated whether effects of prescription opioid misuse on depressive symptoms and suicidality are greater among female than male students.\n\n\nMETHODS\nUsing the 2017 Youth Risk Behavior Survey (N = 14,765), this research estimated additive interactions using risk differences as well as multiplicative interactions using odds ratios.\n\n\nDISCUSSION\nResults showed prescription opioid misuse was associated with significantly greater risks among females than males for depressive symptoms (31.1% vs. 20.8%), suicidal ideation (27.3% vs. 19.1%), suicide attempts (18.1% vs. 11.9%) and suicide attempts requiring treatment (8.5% vs. 4.4%). In contrast, multiplicative interactions using odds ratios were all nonsignificant.\n\n\nCONCLUSIONS\nAmong students who misused prescription opioids, females compared to males had much higher average predicted margins of depressive symptoms, suicidal ideation, suicide attempts, and suicide attempts requiring treatment. Screening for depression and suicidality among adolescents who misuse prescription opioids, and vice versa, is paramount.