Optical Coherence Tomography Angiography to Assess Vascular Remodeling of the Choriocapillaris After Low-Fluence Photodynamic Therapy for Chronic Central Serous Chorioretinopathy.

Abstract

BACKGROUND\nTo evaluate the efficacy of optical coherence tomography angiography (OCTA) in identifying changes in the choriocapillaris layer after low-fluence verteporfin photodynamic therapy (vPDT) in patients affected by chronic central serous chorioretinopathy (CSCR).\n\n\nMETHODS\nLow-fluence vPDT was performed on 28 eyes of 27 patients with CSCR. All patients underwent the following tests at baseline and 6 months after treatment: best corrected visual acuity (BCVA), fluorescein angiography, indocyanine green angiography, enhanced depth imaging OCT and OCTA.\n\n\nRESULTS\nSubretinal fluid was completely absorbed in 18 of the 28 affected eyes (64.3%) after low-fluence vPDT ( responders ), and incompletely absorbed in 10 eyes (35.7%) ( non responders ). BCVA was significantly improved (p\u2009=\u20090.006) whereas central foveal thickness and choroidal foveal thickness were significantly decreased (p\u2009=\u20090.001 and p\u2009=\u20090.00 respectively) 6 months after treatment in responders.\n\n\nCONCLUSIONS\nOCTA revealed a different pattern of vascular remodeling of the choriocapillaris between CSC patients who responded and those who did not respond to low-fluence vPDT.