Meta-analysis of Indocyanine Green Fluorescence Imaging-guided Laparoscopic Hepatectomy.

Abstract

BACKGROUND\nThis meta-analysis was conducted to systematically evaluate the short-term efficacy and safety of indocyanine green (ICG) fluorescence imaging-guided laparoscopic hepatectomy.\n\n\nMETHODS\nA systematic search was conducted of the literature on ICG fluorescence imaging- guided laparoscopic hepatectomy in randomized, semi-randomized controlled trials and observational studies. The found publications and conference papers in English were manually searched and the references included in the literature were traced. The retrieval period was up to February 2021. After evaluating the quality of the included studies, the meta-analysis was conducted using the STATA 15.1 software.\n\n\nRESULTS\nThis meta-analysis included 6\u2002studies comprising 417 patients with liver disease. The meta-results showed that compared to the control group, ICG fluorescence imaging-guided laparoscopic hepatectomy can significantly shorten the operative time [weighted mean differences (WMD)\u202f=\u202f-20.81, 95% CI, -28.02--13.59, P=0.000], reduce intraoperative bleeding [WMD\u202f=\u202f-108.16, 95% CI, -127.88--88.44, P=0.000], shorten hospital stay [WMD= -1.23,95% CI, -1.50--0.95, P=0.000], and reduce the incidence of postoperative complications [OR\u202f=\u202f0.49,95% CI, 0.26-0.91, P=0.025]. There were no differences in blood transfusion, hilar occlusion time, and surgical margin.\n\n\nCONCLUSION\nThe application of ICG fluorescence imaging technology in laparoscopic hepatectomy can effectively reduce the operative time, blood loss, hospital stay and the incidence of postoperative complications. However, more multicenter large-sample randomized controlled trials are needed to further confirm its advantages.