Polyketides metabolites from the marine sediment-derived fungus Thermomyces lanuginosus Tsikl. KMM 4681

Abstract

Abstarct New 1,3,6-trihydroxy-7-(dihydroxypropyl)-anthraquinone (1) and 6-(3′-hydroxybutan-2′-yl)-3,5-dimethyltetrahydro-2H-pyran-2-one (2), along with three previously known compounds, 1,3-dihydroxy-6-hydroxymethyl-7-methoxyanthraquinone (3), 1,3-dihydroxy-6-methyl-7-methoxyanthraquinone (4) and biphenyl-2,2′-diyl-diacetate (5) were isolated from the lipophilic extract of the marine sediment-derived fungus Thermomyces lanuginosus KMM 4681. The structures of the isolated compounds were established based on spectroscopic data. The absolute configurations of the stereocentres of 1 were determined using the time-dependent density functional theory (TD-DFT) calculation of ECD spectra. The effects of 1-4 on viability and colony formation of drug-resistant prostate cancer 22Rv1 and human PNT-2 cells were examined.