Pregnancy hypertension | 2019
Maternal serum lipid levels, oxidative stress and antioxidant activity in pre-eclampsia patients from Southwest India.
Abstract
OBJECTIVE\nA study was carried out to evaluate the effects of metabolic syndrome components and oxidative stress factors among preeclamptic women from South West India.\n\n\nSTUDY DESIGN\nA case-control study was carried out by enrolling fifty pre-eclampsia cases and hundred low-risk pregnant women within the age group of 18-40\u202fyears, at 28-34\u202fweeks of pregnancy. The fasting glucose level, fasting insulin level, insulin resistance, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), malondialdehyde, the ferric reducing ability of plasma (FRAP assay), cardiac output and aortic wall distensibility were measured.\n\n\nMAIN OUTCOME MEASURES\nThere was a significant rise in the fasting blood glucose, fasting insulin, insulin resistance levels, total cholesterol, triglycerides, LDL, and antioxidant levels in pre-eclamptic women (p\u202f<\u202f0.001). The cardiac output and aortic wall distensibility were observed to be low in the cases.\n\n\nCONCLUSION\nWe conclude that abnormal lipid metabolism and high lipid peroxide concentrations observed in pre-eclampsia may result in oxidative stress and vascular dysfunction.