Mortality risk in COVID-19 patients with right bundle branch block

Abstract

Recent analyses have demonstrated that COVID-19 patients with pre-existing cardiovascular risks and/or comorbidities have a higher risk of death in the short-term. However, the prognostic role of right bundle branch block (RBBB) in these patients has not yet been evaluated. The aim of this study was to perform a brief metaanalysis on the prognostic impact of RBBB on short-term mortality in COVID-19 patients. The study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Metaanalyses (PRISMA) guidelines. The MEDLINE and Scopus databases were systematically searched for articles, published in English, from the inception of the COVID-19 pandemic (January 2020) through 1 May 2021 using the following Medical Subject Heading (MESH) terms: ‘‘COVID-19’’ AND ‘‘Arrhythmias’’ OR ‘‘Right bundle branch block’’. Inclusion criteria were: a) studies enrolling participants with a confirmed diagnosis of COVID-19; b) providing data on the presence/absence of RBBB among survivors (S) and nonsurvivors (NS), allowing us to calculate an unadjusted odds ratio (OR) when not provided; and c) reporting all-cause mortality by the presence or absence or RBBB. We excluded case reports, review articles, editorials/letters, and case series with less than 10 participants, randomized controlled trials and studies including duplicate populations and investigations evaluating the electrocardiographic consequences of specific COVID-19 therapy. References from the included studies were screened to potentially identify other investigations meeting the inclusion criteria. Ethical approval and informed consent were not required as the study did not directly enrol human participants. The quality of the included studies was graded using the Newcastle-Ottawa quality assessment scale (NOS). Mortality risk data were pooled using the Mantel-Haenszel random effects models with odds ratios (OR) as the effect measure with 95% confidence intervals (CI). Heterogeneity among studies was assessed using Higgins and Thompson I statistic where I values correspond to the following levels of heterogeneity: low (< 25%), moderate (25%-75%) and high (> 75%). The presence of potential publication bias was verified by visual inspection of the funnel plot. Due to the low number of included studies (< 10), small-study bias was not examined as our analysis was underpowered to detect such bias. A predefined sensitivity analysis (leave-one-out analysis) was performed removing 1 study at a time, to evaluate the stability of our results. All meta-analyses were conducted using Comprehensive Meta-Analysis software, version 3 (Biostat, United States). The initial search resulted in 2049 articles (951 in PubMed and 1098 in Scopus, respectively). After we removed duplicates (n = 885) and applied our inclusion criteria, 6 studies, enrolling 1904 patients (mean age 64.7 years old, 1176 males) were included in the analysis. All the investigations were of high quality according to the NOS. The most frequent comorbidities were arterial hypertension and diabetes mellitus. Conversely, the prevalence of heart failure, coronary artery disease and chronic obstructive pulmonary disease were not systematically reported in the reviewed investigations, making a comprehensive evaluation impossible (table 1). The mortality rate was 17.0% (n = 324). RBBB was present in 150 COVID-19 participants (7.8% of cases). On pooled analysis, RBBB was significantly associated with a higher risk of death in the short-term (OR, 2.96; 95%CI, 2.04-4.30; P .0001; I = 0%) (figure 1A). Visual inspection of the relative funnel plot revealed no significant evidence of publication bias (figure 1B). Sensitivity analysis slightly changed the combined OR, which remained statistically significant across a range from 2.38 (95%CI,1.48-3.84) to 3.24 (95%CI, 2.16-4.85), suggesting that no single study had an undue impact on the study outcome. The results of present analysis suggest a higher mortality risk in COVID-19 patients with RBBB. We decided to analyze the impact on RBBB since several analyses have demonstrated that right ventricular dysfunction is frequently observed in COVID-19 patients and is associated with a poor prognosis. Because RBBB is an electrocardiographic sign of right ventricular strain and considering that right ventricular dysfunction is generally due to pulmonary microembolic events in COVID-19 patients, we hypothesized that this conduction disturbance may be related Rev Esp Cardiol. 2021;xx(x):xxx–xxx