Reumatologia clinica | 2019
Asymptomatic Hyperuricaemia and Coronary Artery Disease.
Abstract
BACKGROUND\nUric acid has been related to a tendency to precipitate to form crystals, presenting asymptomatically, until the formation of arthritis, tophi or renal lithiasis. Previously, the presence of asymptomatic hyperuricaemia has been associated with the presence of cardiovascular disease.\n\n\nOBJECTIVES\nTo determine the association of complex coronary artery disease in patients with asymptomatic hyperuricaemia.\n\n\nMATERIAL AND METHODS\nAn observational retrospective, transversal, unicentric study was conducted in a tertiary hospital in Mexico, in the period from June 2017 to March 2019. All patients admitted for coronary angiography were included; patients with gout, use of diuretics and chronic kidney disease were excluded.\n\n\nRESULTS\nDuring the study period, a total of 300 patients were collected, of which 40% presented hyperuricaemia. The patients with hyperuricaemia were older (59 vs. 63, P\xa0=\xa0.002). The group of patients with asymptomatic hyperuricaemia had a higher proportion of complex coronary lesions (64 vs. 35%, P\xa0≤\xa0.0001) as well as a higher SYNTAX I score (27 vs. 17, P\xa0≤\xa0.001). There was a higher probability of presenting complex coronary lesions in this group of patients (OR 3.4, P\xa0≤\xa0.0001). In addition, in the group division of uric acid levels, it was related to the presence of complex coronary lesions (Q1 = .5, P\xa0=\xa0.06), (Q2 = 2, P\xa0=\xa0.01) and (Q3 = 3, P\xa0≤\xa0.0001).\n\n\nCONCLUSION\nAsymptomatic hyperuricaemia has a higher prevalence and association of presenting complex coronary lesions.