Eveningness chronotype preference among individuals at clinical high risk for psychosis

Abstract

BACKGROUND\nCircadian rhythm disturbances are frequently implicated in psychosis. Indeed, research has suggested several avenues by which circadian rhythms may play a mechanistic role as well as contribute to clinical outcomes. Despite its potential role as a risk factor, little is known about circadian rhythm disruption among individuals at clinical high risk (CHR) for psychosis, clinical correlates, or specificity to the psychosis risk syndrome.\n\n\nMETHODS\nEighty-four CHR, 74 individuals with depressive disorders (DD), and 101 non-psychiatric controls (NPC) participated in structured clinical interviews and provided self-reports of chronotype preference. Clinical (positive, negative, anxious, and depressive symptoms) and social functioning outcomes were self-reported and/or clinician-rated. Analyses of covariance controlling for demographics examined group differences in chronotype preference, and partial Pearson correlations evaluated associations with clinical/functional outcomes.\n\n\nRESULTS\nGroup differences were observed (F(11, 246)\xa0=\xa08.05, p\xa0<\xa0.001) with CHR and DD individuals indicating greater eveningness preference compared to NPC. A follow-up sensitivity analysis examining CHR participants with (n\xa0=\xa025) and without (n\xa0=\xa059) depressive disorders indicated no difference in chronotype preference (F(10,72)\xa0=\xa00.00, p\xa0=\xa0.99). Greater eveningness preference was related to greater negative symptoms (i.e., avolition; r\xa0=\xa0-0.25) and anxiety (r\xa0=\xa0-0.34) among CHR individuals.\n\n\nCONCLUSIONS\nCHR and DD display greater preference for eveningness chronotype compared to NPC indicating the disruption is associated with a range of mental health concerns, and not specific to the psychosis-risk syndrome. However, comorbidity with DD did not appear to be driving the finding in the CHR group. Further research may examine shared versus non-shared underlying mechanisms contributing to chronotype preference across psychiatric presentations.