Prioritization of antibiotic contaminants in China based on decennial national screening data and their persistence, bioaccumulation and toxicity.

Abstract

The potential adverse impacts of antibiotic contamination on environmental quality are generating increasing concern. Given that an alarming amount and variety of antibiotics have been used in China, a list of priority antibiotics is urgently needed to develop regulatory frameworks to control antibiotic use and monitor environmental pollution. This study established a new method of ranking priority antibiotics based on their prevalence (Pv), occurrence (O), persistence, and bioaccumulation, and toxicity (PBT) in the environment. The Pv and O criteria were weighted and quantified using the decennial national screening datasets (>15,000 concentration values for 105 candidate antibiotics in eight environmental compartments), and quantitative structure-activity relationships were used to estimate PBT values. A total of 26 high priority antibiotics were identified using the PvOPBT method, including 8 quinolones, 5 sulfonamides, 5 macrolides, 4 tetracyclines, 3 from other classes, and 1 unclassified antibiotic. For individual antibiotic classes, the β-lactams and aminoglycosides were ranked from no priority to low priority, whereas the macrolides and tetracyclines were ranked from medium to high priority. Although the PvOPBT ranking scores for the aqueous and solid phases demonstrated an apparent difference for some candidate antibiotics, eighteen antibiotics were ranked as high priority in both aqueous phases and solid phases and are suggested as the top priorities worthy of immediate attention. These top priority antibiotics are primarily utilized in animal husbandry within China. Therefore, urgent action is needed to limit the use of these top priority antibiotics in the animal industry.