Seminars in arthritis and rheumatism | 2019
Quantitative subchondral bone perfusion imaging in knee osteoarthritis using dynamic contrast enhanced MRI.
Abstract
OBJECTIVE\nSubchondral bone changes, characterized by increased bone turnover and vascularity, are believed to stimulate progression and pain in knee osteoarthritis (OA). The objective of this study was to evaluate the bone perfusion in knee OA using quantitative dynamic contrast enhanced MRI (DCE-MRI).\n\n\nDESIGN\nUnicompartmental knee OA patients were included and underwent 3 Tesla DCE-MRI and T2-weighted MRI. Quantitative DCE-MRI analysis of Ktrans and Kep, representing perfusion parameters, was performed to evaluate differences between the most and least affected knee compartment. First, DCE-MRI parameter differences between epimetaphyseal and subchondral bone in both femur and tibia were assessed. Second, DCE-MRI parameters in subchondral bone marrow lesions (BMLs) were compared to surrounding subchondral bone without BMLs.\n\n\nRESULTS\nTwenty-three patients were analyzed. Median Ktrans and Kep in epimetaphyseal bone were significantly higher (p\u202f<\u202f0.05) in the most affected (Ktrans: 0.014; Kep: 0.054\xa0min-1) compared to least affected (Ktrans: 0.010; Kep: 0.016\xa0min-1) compartment. For subchondral bone, DCE-MRI parameters were significantly higher (p\u202f<\u202f0.05) in the most affected (Ktrans: 0.019; Kep: 0.091\xa0min-1) compared to least affected (Ktrans: 0.014; Kep: 0.058\xa0min-1) compartment as well. Subchondral BMLs detected on fat-saturated T2-weighted images were present in all patients. Median Ktrans (0.091 vs 0.000\xa0min-1) and Kep (0.258 vs 0.000\xa0min-1) were significantly higher within subchondral BMLs compared to surrounding subchondral bone without BMLs (p\u202f<\u202f0.001).\n\n\nCONCLUSIONS\nIncreased perfusion parameters in epimetaphyseal bone, subchondral bone and BMLs are observed in unicompartmental knee OA. BMLs likely account for most of the effect of the higher bone perfusion in knee OA.