Sensors and Actuators B: Chemical | 2021
Nanohybrid electrocatalyst based on cobalt phthalocyanine-carbon nanotube-reduced graphene oxide for ultrasensitive detection of glucose in human saliva
Abstract
Abstract The current diabetes management systems require collecting blood samples via an invasive and painful finger pricking leading to the formation of callus, scarring and loss of sensibility to patients due to continuous monitoring. Therefore, a non-invasive and painless method of determining glucose levels would be desirable to diabetes patients who need constant monitoring. Saliva glucose measurement is a non-invasive alternative for diabetes management. A highly sensitive, stable, and selective non-enzymatic electrochemical sensor that can accurately quantify saliva glucose is required. A single-walled carbon nanotube/reduced graphene oxide/cobalt phthalocyanines nanohybrid modified glassy carbon electrode (GCE-SWCNT/rGO/CoPc) has been fabricated for the non-enzymatic determination of glucose in human saliva. The SWCNT/rGO/CoPc was characterized using various spectroscopic, microscopic, and electrochemical techniques. The synergistic effect between SWCNT, rGO, and CoPc facilitated an excellent electron transfer process that improves the sensor sensitivity. The GCE-SWCNT/rGO/CoPc sensor exhibited two linear responses in the 0.30\xa0μM to 0.50\xa0mM and 0.50\xa0mM to 5.0\xa0mM glucose concentration ranges, and the detection limit was 0.12\xa0μM. The sensor had an excellent saliva glucose detection sensitivity of 992.4 μA.mM-1.cm-2 and high specificity for glucose in the presence of other coexisting analytes. In addition, it showed good storage stability, reusability, and a fast response time of about 1.2\xa0s. The GCE-SWCNT/rGO/CoPc nanohybrid showed an excellent potential for developing accurate, non-invasive, and painless glucose sensor.